2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Aldehyde Oxidase (AO)

Aldehyde Oxidase (AO) (醛氧化酶)

Aldehyde Oxidase; AO

Aldehyde Oxidase is a soluble cytoplasmic molybdenum-containing enzyme that is mainly involved in the biotransformation of various drugs and xenobiotics. Aldehyde Oxidase has four isoforms (AOX1, AOX3, AOX3L1, and AOX4). Aldehyde Oxidase is mainly expressed by the liver, but is distributed widely in the lungs, kidneys, brain, and skin. Aldehyde Oxidase catalyzes oxidation and reduction reactions, among which the oxidation of aldehydes, nitro/nitroso compounds or N-heterocycles are more common. Aldehyde Oxidase affects drug metabolism, impacts drug interactions, and generates potential toxic metabolites. Aldehyde Oxidase could lead to liver damage (such as NAFLD), renal toxicity and amyotrophic lateral sclerosis (ALS)[1][2].

Aldehyde Oxidase (AO) 相关产品 (1):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-13735
    Quinacrine Inhibitor 98.20%
    Quinacrine (Acriquine) 是一种抗疟疾和抗癌剂。Quinacrine 还抑制人醛氧化酶 (aldehyde oxidase) (IC50: 3.3 μM)。Quinacrine 对核酸具有亲和力，并对固定细胞中的 DNA 和 RNA 染色 (Ex/Em: 436/525 nm)。
    Quinacrine
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